Communication & Dissemination Leader
Steinbeis Europa Zentrum (SEZ)
To decipher the mechanisms and events triggering health-to-disease transition, the project will study the pathogenesis of RDs by:
The 48-months project will be executed through nine highly interdependent Work packages (WP)
WP1 – Population cohort analysis to explore biomarkers & lifestyle factors influencing health – Leader: HUS
This WP aims to identify features of the microbiota which promote chronic inflammation (CI) and systemic endotoxemia (SE) and increase the risk of rheumatic diseases (RD) by the analysis of population cohorts. This work sets basis for the discovery of novel biomarkers and proteomic profiles for intestinal dysbiosis, SE and RDs.
WP2 - Focused cohorts and in vitro studies addressing gut permeability and Systemic Endotoxemia – Leader: UNICAM
By the analysis of population cohorts and in vitro assays, WP2 aims to elucidate the association of microbiota dysbiosis, specific members of the microbiota and their effector molecules with the immune system and CI.
WP3 – Proof of Concept Studies regarding systemic and local mechanism driving intra-articular Systemic Endotoxemia & joint inflammation- Leader: SERGAS
WP3 aims to characterize bacterial derived compounds such as lipopolysaccharide (LPS) and their molecular interactions with proteins and receptors involved in SE-related inflammatory responses.
WP4 - Novel Strategies to prevent and control arthritis by interfering with the gut-joint axis – Leader: iMM
WP4 will study new dietary and drug interventions like Larazotide in modulating the microbiota, intestinal permeability and RDs disease activity. Thereby, novel Strategies to prevent and control arthritis by interfering with the gut-joint axis will be developed.
WP5 - Data management, multiomics modelling and Artificial intelligence – Leader: SIB
WP5 will extract, standardise and harmonise data from multiple large population studies and prepare them for analysis. This WP is responsible for the validation of derived parameters, biomarkers and pathways by utilizing Machine learning (ML) and Artificial intelligence (AI) analysis.
WP6 – Ethics, Regulation & General Data Protection Regulation (GDPR) – Leader: EBRIS
WP6 will carefully handle the ethical considerations for personal, clinical and AI data. Furthermore, WP6 will handle GDPR compliance and will ensure that data is stored in a suitable robust manner.
WP9 – Ethics requirements – Leader: HUS
The objective of this WP is to ensure compliance with the ‘ethics requirements’ set out in this work package.
WP7 - Dissemination, Exploitation and Communication – Leader: SEZ
WP7 will ensure transparent and successful dissemination, exploitation and communication, of the project’s results. This includes effective dissemination and communication of the project results to industry, media, the scientific community, end users and the general public. Furthermore, WP7 will provide exploitation support for best possible usage and sustainability of the project’s results.
WP8 – Project Management – Leader: HUS
The main objective of WP8 is to ensure the timely and qualitative achievement of project results through effective administration and leadership. Another focus is to ensure the quality control of project results and risk management of the project. This WP provides timely and efficient financial management of the project and the compliance with contractual commitments.